05. March 2018
Water-soluble polymers with high viscosity are frequently used in the design of sustained-release formulations of poorly water-soluble drugs to enable complete release of the drug in the gastrointestinal tract. Tablets containing matrix granules with a water-soluble polymer are preferred because tablets are easier to handle and the multiple drug-release units of the matrix granules decreases the influences of the physiological environment on the drug.
15. February 2018
Polymer physical gels have been used in numerous practical applications within food processing, chemical, cosmetics, pharmaceutical and agricultural industries. They may be obtained on the bases of synthetic and natural polymers. Natural polymers are easily biodegradable, hence their more extensive usage within the areas where synthetic polymers have been applied so far.
13. November 2017
Amorphous solid dispersions (SDs) are considered as one of the most effective strategies for the formulation of poorly water-soluble compounds. The active compound is dispersed in an inert carrier composed of a polymer and active excipients. Since the drug is amorphous, there is typically an increase in apparent solubility as well as dissolution rate. Various methods are employed for manufacturing of SDs, nevertheless, hot-melt extrusion (HME) has become one of the most common process techniques
30. June 2017
The purpose of this study is to evaluate the photostabilization mechanism of risperidone tablets. Risperidone is
widely used for sensory integration disorder. It is formulated as tablets, orally disintegrating tablets, fine granules,
oral solutions, and intramuscular injections.
15. December 2016
Abstract The study aims to elucidate the transformations of anhydrous olanzapine Form I (OLZ FI) into the hydrate forms, when stored at a high relative humidity or suspended in an aqueous media, in the presence of polymers. OLZ FI and physical mixtures (3:1 and 1:1, as powders or compacts) of olanzapine with polyethylene glycol (PEG-6000), polyvinylpyrrolidone (PVP K25) and hydroxypropylcellulose (HPC-LF) were stored (75%RH/25 °C, 75%RH/40 °C and 93%RH/25 °C) for 28 days. OLZ FI and the...
24. October 2016
Abstract The objective of this study is to design novel dissolution-enhanced microparticles loaded poorly soluble drug nanocrystals used a low viscosity of hydroxypropylcellulose (HPC) as matrix carrier. An interesting approach combined homogenization and the spray-freeze-drying technique was developed. The results demonstrated that the ratio of HPC to drug played an important role in size-reduction efficiency of drug during homogenization. And the formation of cage-like structure of the...
20. June 2016
Highlights • Ophthalmic viscoelastic devices (OVDs) were designed composed of HPC and ɩ-carrageenan (Carr). • The rheological and compressional properties of the polymer blends were characterised. • HPC and Carr were shown to physically interact in both dilute and gel states. • Binary platforms offered a wide range of rheological and compressional properties. • Platforms containing 3% HPC and 1% or 2% Carr exhibited properties advantageous for use as OVDs Read more...
09. January 2016
In this work, alginate, alginate-pectin and alginate-hydroxypropylcellulose pellets were produced by ionotropic gelation and characterized. Ibuprofen was selected as model drug; it was suspended in the polymeric solution in crystalline form or dissolved in a self-emulsifying phase and then dispersed into the polymeric solution. More