10. March 2018
Mucoadhesive tablets for administration in buccal mucosa are unconventional formulations with many technological attractions. However there is no standardization of information for its formulation. The present article aims to evaluate, by means of a systematic review with meta-analysis, the data related to the final quality of this technology.
19. February 2018
The effects of tablet preparation and subsequent film coating with amorphous solid dispersion (ASD) particles that were composed of a drug with poor water solubility and hydrophilic polymers were investigated. ASD particles were prepared with a drug and vinylpyrrolidone–vinyl acetate copolymer (PVPVA) or polyvinylpyrrolidone (PVP) at a weight ratio of 1:1 or 1:2 using a melt extrusion technique. Tablets were prepared by conventional direct compression followed by pan coating. A mathematical...
15. February 2018
Polymer physical gels have been used in numerous practical applications within food processing, chemical, cosmetics, pharmaceutical and agricultural industries. They may be obtained on the bases of synthetic and natural polymers. Natural polymers are easily biodegradable, hence their more extensive usage within the areas where synthetic polymers have been applied so far.
13. November 2017
Amorphous solid dispersions (SDs) are considered as one of the most effective strategies for the formulation of poorly water-soluble compounds. The active compound is dispersed in an inert carrier composed of a polymer and active excipients. Since the drug is amorphous, there is typically an increase in apparent solubility as well as dissolution rate. Various methods are employed for manufacturing of SDs, nevertheless, hot-melt extrusion (HME) has become one of the most common process techniques
09. October 2017
Tablets with HPMC/CH are the most suitable for vaginal controlled release of TFV.
HPMC/CH tablets show vaginal mucoadhesion time according to the TFV release time. A higher proportion of CH than HPMC has a moderate swelling and faster erosion
12. June 2016
Introduction: Amorphous solid dispersions are considered as one of the most powerful strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical ingredient (API) dispersed at the molecular level in an amorphous polymeric carrier. As the latter component constitutes the largest part of the formulation, its characteristics will contribute to a large extent to the properties and behavior of the solid dispersion. Areas covered: Amorphous polymers are most often used...
11. August 2015
The development of inhaled products to treat or to prevent lung infection is a very active research field in drug delivery. The pulmonary route is extremely attractive but very challenging. This paper reports the study of excipient, capsule brand and device influence on the aerodynamic behavior of dry powder formulations to treat tuberculosis. More