18. April 2017
Abstract This work was carried out to explore the unknown area of converting non-woven fibres, prepared by high speed electrospinning, into a directly compressible blend by mixing with excipients. An experimental design, with independent variables of compression force and fillers fraction, was realized to investigate tabletability of electrospun material (EM) and to produce hard tablets with appropriate disintegration time. The models proved to be adequate; fitted to the results and predicted...
26. March 2017
Aim: Telmisartan is an anti-hypertensive drug under the class of angiotensin II receptor blocker. The aim is to formulate and evaluated immediate release telmisartan tablets using hydrophilic polymers. Materials and Method: The hydrophilic polymers are polyethylene glycol 4000 (PEG-4000) and PEG-6000. Solid dispersion is prepared with polymers with different ratios 1:0.5, 1:1, 1:2 and formulated into tablets. Formulations were characterized for drug content studies, drug release studies, and...
19. October 2016
Abstract Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. The basic approach used in development tablets is the use of superdisintegrant, Tablet molding technique, Direct compression...
13. August 2016
Abstract Purpose The fabrication of ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing. Methods Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer...
18. March 2016
Abstract: The objective of this study was to design and evaluate Sitagliptin Phosphate immediate release (IR) 50 mg tablet using Response Surface Methodology for the managemant of Type-II diabetes mellitus. Response surface methodology (RSM) computations for this optimization study were performed employing Minitab 16. Different formulations of immediate release were prepared by applying 2 factor 2 level Central Composite Design (CCD) using Minitab 16 which gave 13 formulation for each layer....
21. December 2015
There is evidence that processing techniques like hot-melt extrusion (HME) could alter the mechanical properties of pharmaceuticals, which may impede further processability (e.g. tableting). The purpose of this study was to evaluate if HME has an impact on the tableting behavior of polyvinyl alcohol (PVA) – formulations. More
07. December 2015
Multiparticulate dosage forms are a recent strategy to meet the special needs of children, elderly people and patients suffering from dysphagia. Our study presents a novel and cost-efficient approach for the manufacturing of a taste-masked multiparticulate system with a stable immediate release profile by applying lipid-based excipients in a solvent-free hot melt coating process. More
30. November 2015
Multiparticulate dosage forms are a recent strategy to meet the special needs of children, elderly people and patients suffering from dysphagia. Our study presents a novel and cost-efficient approach for the manufacturing of a taste-masked multiparticulate system with a stable immediate release profile by applying lipid-based excipients in a solvent-free hot melt coating process. More