04. October 2018
The aim of this work was to develop an ascending controlled-release pellet (ACRP) of paliperidone to improve poor solubility and provide a stable blood drug concentration. The inner core was produced by mixing different ratios of sodium chloride as an osmotic substance and microcrystalline cellulose (MCC) to offer a pressure drive when in contact with medium. After, the drug layer was processed by a liquid-layering method, with paliperidone ground to a nano-size in order to improve the...
13. October 2017
Osmotic pump delivery systems have made significant advances in the past decades for controlled drug release over a long period of time. Usually, osmotic pump products require sophisticated and expensive laser drill technology resulting in increase in production cost and decrease in production efficiency. In this study, a lamotrigine extended release tablet based on a controlled-porosity osmotic pump (CPOP) system was developed to circumvent laser drill technology in reference, Lamictal XR®....
14. February 2017
Abstract In controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and pore former (hydrophilic) is extremely challenging. Therefore, the aim of the present investigation was to tackle the issue associated with controlled porosity osmotic pump (CPOP) system using nano-suspension coating method. In the present study 4-Amino pyridine was used as a highly water soluble drug. In this method, a hydrophilic pore former...
09. February 2017
ABSTRACT Objective: In the present study, our objective was to develop porous osmotic pump tablets of an anti-Parkinson’s agent, ropinirole. It also aimed to demonstrate the applicability of factorial designs and there by a statistical optimization in developing a controlled drug releasing device. Methods: A 32 factorial D-optimal study design was adopted to identify an optimized formulation. Tablets were prepared by direct compression using varying amounts of microcrystalline cellulose (MCC)...
02. June 2016
In this study, osmotically controlled drug delivery system of Nifedipine using different polymers were formulated. Nifedipine, is an anti-hypertensive drug. It acts as a calcium channel blockers. Unlike any other conventional dosage forms in osmotic system, the mechanism involved is osmosis. In the present studies, the release of the drug is porosity.A total of nine formulations were prepared by using the different polymers (Poly Ethylene oxide, HPMC K15 M and Ethyl cellulose) in different...
21. March 2016
The development of oral controlled release system has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. Various physical and chemical approaches have been applied to produce a well characterized dosage form that controls drug input into the body within the specifications of the desired release profile. This is generally accomplished by attempting to obtain “zero-order” release from the dosage...