Oral Controlled-Release Solid Dosage Forms, Use of Novel Polymer and Unconventional Polymer Blends
Use of unconventional polymer blends of Kollicoat® SR 30 D and Eudragit® RL 30 D:
Among the dissolution test conditions, hydrodynamic properties (agitation rate) and mechanical destructive force are important factors, which affect the dissolution behavior of the dosage form. In hydrogel-type tablets, in vivo drug release was much faster than that expected from in vitro dissolution tests due to the peristalsis of the gastrointestinal tract. Moreover, because single-unit reservoir tablets required a strong/flexible and permeable polymer, there are few publications in this respect, due to lack of polymer with these properties.
Among the dissolution test conditions, hydrodynamic properties (agitation rate) and mechanical destructive force are important factors, which affect the dissolution behavior of the dosage form. In hydrogel-type tablets, in vivo drug release was much faster than that expected from in vitro dissolution tests due to the peristalsis of the gastrointestinal tract. Moreover, because single-unit reservoir tablets required a strong/flexible and permeable polymer, there are few publications in this respect, due to lack of polymer with these properties.