16. August 2018
The aim of this study was to investigate whether floating microspheres prepared from polymer blends of hydroxypropyl methylcellulose in combination with either Eudragit S100 or Eudragit RS100 could improve the systemic bioavailability of the antiemetic drug; meclizine HCl (MCZ). Floating microspheres containing MCZ were prepared by emulsion solvent evaporation method. The influence of different polymer blend compositions on various formulation parameters and in vitro release characteristics of...
04. September 2017
Abstract The aim of this study was to develop and characterize sustained release vildagliptin (VLG) loaded Eudragit® RS-100 microspheres. The microspheres were prepared by single emulsion [oil-in-oil (O/O)] solvent evaporation method. Plackett–Burman design (PBD) was employed by using Design-Expert®Software to screen and understand impact of five independent formulation factors such as Eudragit® RS-100 (A), span-80 (B), acetone (C), methanol (D), stirring speed (E) affecting on...