05. December 2017
Active Freeze Drying allows for producing lyophilised powders by progressive agitation of frozen blocks undergoing sublimation. One potential application of this process is the formulation design of unstable nanosuspensions for oral drug delivery, as here shown for nanocrystal-based ketoconazole powder.
09. November 2017
The solubility-permeability interplay deals with the question: what is the concomitant effect on the drug‘s apparent permeability when increasing the apparent solubility with a solubility-enabling formulation? The solubility and the permeability are closely related, exhibit certain interplay between them, and ongoing research throughout the past decade shows that treating the one irrespectively of the other may be insufficient.
26. May 2015
The present work focusses on the formulation development and evaluation of functional excipient (surfactant stabilizer), Vitamin E TPGS loaded self-nanoemulsifying drug delivery system (SNEDDS) for improving deliverability and safety profile of Cyclosporine A (CyA)…. Sanyog Jain, Sindhu Kambam, Kaushik Thanki and Amit K Jain RSC Adv., 2015, Accepted Manuscript DOI: 10.1039/C5RA04762E Received 18 Mar 2015, Accepted 20 May 2015 First published online 20 May 2015...