08. May 2017
Bilayer tableting is frequently used for the formulation of
fixed dose combination (FDC) tablets containing two active
pharmaceutical ingredients (APIs). The fundamental structure
of bilayer tablets allows for the degree of physical contact
between the APIs to be minimized to avoid the potential for
unwanted chemical reactivity,
25. June 2016
Abstract Multilayer/bilayer tablets have been applied for the formulation of incompatible components for compound preparations, but more often they are used to modify drug release. The objective of this study was to explore the feasibility of developing, using a bilayer tablet strategy, an immediate- and extended-release formulation of amoxicillin. The formulation of each layer was optimized separately and the bilayer tablets were compressed at an immediate/extended layer weight ratio of 3:7....
07. January 2016
The present investigation studied a novel bilayer tablet having extended release of rosuvastatin calcium (RSTCa) and immediate Release of fenofibrate (FB) in different polymers using wet granulation techniques. Granules were characterized by fourier-transformed Infrared Spectroscopy (FT-IR), differential Scanning Calorimetry (DSC), as well as by content uniformity, in-vitro dissolution studies and release kinetics. Selected granular system was subjected to bilayer tablet preparation by direct...