02. May 2017
Highlights
• Binder properties were correlated to granule and tablet properties.
• Groups of binders behave divergent regarding granule and tablet properties.
• Povidone based polymers seem to have another binding behaviour.
• Disintegration of tablets was explained by particle size and viscosity effects.
• Changes in particle size caused larger effects for small-sized binders on tablets.
15. March 2016
As dry granulation as a continuous process becomes steadily more important, the interest of different materials and their processing is growing. Binders are of high importance as they have to compensate granule hardening, reduce the fines, and ensure adequate tablet tensile strengths. A simple formulation was used for roll compaction/dry granulation with subsequent tableting to produce granules and tablets, containing paracetamol (70% w/w), a filler and a binder (10%). With this formulation...