17. August 2018
This webinar explores how the choice of excipients can improve API stability in a solid dosage drug formulation. Abstract Many factors in a drug formulation can have a negative effect on the stability of the API, which can result in a reduced shelf life, less effective medicinal effect on the patient, or in the worst cases, harm to a patient. API stability can be negatively affected by various factors, including excipients. This webinar explores how the choice of excipients can improve API...
04. July 2018
It is well recognised that the historical timeline required for developing a drug, beginning with target identification and validation, is long and often tedious. It requires a large set of competences in various areas of molecular and cellular biology, chemistry, pharmacology, imaging, and model animal experimentation. Once the active molecule appears to be ready for human testing in controlled clinical trials, then the question arises of how to formulate it to render it stable, adequately...
20. May 2018
The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety, effectiveness and delivery of the drug. These substances have been appropriately evaluated for safety (1). Although excipients are well characterized and evaluated for safety, they can interact with the API chemically or physically (2). An incompatibility...
03. May 2018
The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety, effectiveness and delivery of the drug. The 1968 phenytoin intoxication outbreak in Brisbane, Australia, is a classic example of an API-excipient interaction. When administered with CaSO4 the absorption of phenytoin was reduced due to an interaction between...
09. February 2016
Excipients are more complex than well-characterized active pharmaceutical ingredients (“APIs”). Often, it is the multi-component nature of the excipient that drives many of the interactions with APIs. Even for the most commonly used excipients, it is necessary to understand the context of their manufacture in order to identify potential API interactions with trace components. This workshop will illustrate the contrasting nature of excipients, and help identify reaction mechanisms. This...