14. October 2017
Over the last two decades, regulatory agencies have demanded better understanding of pharmaceutical products and processes by implementing new technological approaches, such as process analytical technology (PAT). Process analysers present a key PAT tool, which enables effective process monitoring, and thus improved process control of medicinal product manufacturing. Process analysers applicable in pharmaceutical coating unit operations are comprehensibly described in the present article. The...
15. August 2016
Abstract The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carr index (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very common in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic silica on a poorly flowable active pharmaceutical ingredient (ibuprofen) by different flow characterization techniques. Different percentages (0.5, 1.0, and 2.0 wt%) of both types of mixed...
01. November 2015
Highlights Development of a new biorelevant dissolution method for orodispersible films, considering mechanical force, saliva flow, volume and composition. Comparison of different conventional methods and the new biorelevant dissolution method regarding their consideration of in vivo conditions. Feasibility and problems of different dissolution setups for orodispersible films. Conventional dissolution setups show faster concentration onset compared to the new developed biorelevant setup. The...