04. September 2017

Abstract The aim of this study was to develop and characterize sustained release vildagliptin (VLG) loaded Eudragit® RS-100 microspheres. The microspheres were prepared by single emulsion [oil-in-oil (O/O)] solvent evaporation method. Plackett–Burman design (PBD) was employed by using Design-Expert®Software to screen and understand impact of five independent formulation factors such as Eudragit® RS-100 (A), span-80 (B), acetone (C), methanol (D), stirring speed (E) affecting on...

14. August 2017

Insulin, a hormonal drug for the management of diabetes mellitus has continued to attract attention of many researchers and pharmaceutical formulators for more than a decade. However, its low oral bioavailability due to the activities of intestinal enzymes restricts its route of administration to only the parenteral route.

04. January 2017

Abstract This research addresses the development and in vitro evaluation of a microparticulate system intended for intestine-targeted delivery of curcumin (CRM), a natural polyphenol with anti-inflammatory properties. Microspheres (Ms) based on zein (ZN) and Gantrez® AN119 (PVMMA) were prepared by spray-drying and coated with a pH-sensitive polymer (Eudragit® FS30D). An experimental design was performed to optimize the microparticulate formulation. A detailed characterization of systems was...

18. September 2016

Aim: In the present study, the main objective was to develop a multiparticulate system containing chitosan microspheres for colon-specific drug delivery of capecitabine for the treatment of colorectal cancer. Materials and Methods: This study was based on the microbial degradability of chitosan microspheres. The microspheres were prepared with chitosan by emulsion cross linking method. A factorial design was applied to optimize the formulation. The effect of concentration of chitosan and drug:...

14. August 2016

Abstract The colon is a promising site for drug targeting owing to its long transit time and mild proteolytic activity. The aim of this study was to prepare new low methoxy amidated pectin/NaCMC microspheres cross-linked by a mixture of Zn2+ and Al3+ ions and test their potential for colonic targeting of progesterone. A 24 factorial design was carried out to optimize the preparation conditions. High drug entrapment efficiency (82–99%) was obtained and it increased with increasing drug...

20. July 2016

Abstract Objective: A novel multiparticulate system for the gastric delivery of Diltiazem (DTZ) was developed for effective treatment of hypertension. Materials and methods: Floating microspheres of ethylcellulose and Eudragit loaded with DTZ were successfully developed and evaluated for their gastro-retentive and controlled-release properties. The effect of various process variables on the particle morphology, micromeritic properties, in vitro floating behavior, percentage drug entrapment, and...

14. July 2016

As a novel drug delivery approach, piroxicam an anti rheumatoid drug is loaded in microspheres prepared by chitosan as a polymer and coated with eudragit S-100 to prepare colon speci c microspheres which increases the bioavailability of the drug to the targeted area and in a controlled manner and reduces GI related side effects. In the present study chitosan microspheres were prepared using emulsion crosslinking technique, glutaraldehyde as a crosslinker and microencapsulation using phase...

04. July 2016

Abstract Nowadays electronic tongues are used for the recognition of variety of samples, but most popular application area is pharmaceutical analysis, including mainly taste masking effects detection and estimation. However, it is noticeable, that among various pharmaceutical formulations still simple masking with the use of sweeteners plays the key role in such investigation. In this work we conduce electronic tongue study of novel drug delivery system − microspheres containing cetirizine....