04. January 2017
The aim of the present work was to develop and optimize multiparticulate formulation viz. pellets of naproxen by employing QbD and risk assessment approach. Mixture design with extreme vertices was applied to the formulation with high loading of drug (about 90%) and extrusion-spheronization as a process for manufacturing pellets. Independent variables chosen were level of microcrystalline cellulose (MCC)—X1, polyvinylpyrrolidone K-90 (PVP K-90)—X2, croscarmellose sodium (CCS)—X3, and...
28. July 2016
Abstract Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and...
29. March 2016
Microcrystalline Cellulose (MCC) pellets containing highly water soluble compound A was formulated with highest pellet usable yield of 86%, aspect sphericity that is (aspect ratio less than 1.1 and roundness greater than 0.85), minimum friability of 0.33% by extrusion and Spheronization technique. A Central Composite Design (CCD) was executed to estimate the effect of formulation and process variable namely water (21-41%), spheronization time (1-9 min) and Spheronization speed (200-800) to...
16. November 2015
Flurbiprofen is a slightly water soluble, nonsteroidal anti-inflammatory active ingredient with analgesic and antipyretic activity. The purpose of this study was to develop an appropriate pellet production method for pH independent sustained release pellet formulation of flurbiprofen. Flurbiprofen pellets were produced by three different production methods; Suspension Layering, Extrusion Spherization, Rotagranulation. Although the simple and fast processing properties of Extrusion...
05. October 2015
Highlights •Alginate pellets are prepared by air-pressurized melt pelletization technique. •Melt pelletization is conducted in a high shear mixer. •Air-pressurized melt pellets exhibit slow drug release characteristics. •Pellet consolidation within short processing time sustains drug release. •Prolonged air bubbling induces porous core that fails to sustain drug release. More
07. June 2015
The purpose of this study was to investigate the effect of pelletization aids, i.e., microcrystalline cellulose (MCC) and cross-linked polyvinyl pyrrolidone (XPVP), and filler, i.e., lactose, particle size on the surface roughness of pellets. Pellets were prepared from powder blends containing pelletization aid/ lactose in 1:3 ratio by extrusion–spheronization. Surface roughness of pellets was assessed quantitatively and qualitatively using optical interferometry and scanning electron...
03. February 2015
The extended-release performance of drug-loaded pellets manufactured by two methods, drug layering and direct pelletization, was compared. Mar 02, 2014 by Ed Godek Pharmaceutical Technology http://www.pharmtech.com/comparing-drug-layering-and-direct-pelletization-processes