08. October 2016
Abstract The number of topical fungal infections is growing, mostly owing to immunosuppressive therapy. Several topical fungal infections, such as eye mycoses, can be treated by local administration of antimycotic drugs. One major group of the antifungal agents is triazole, such as voriconazole (VCZ), which is used as the first line treatment of aspergillosis. A disadvantage of VCZ is its low water solubility making the drug difficult to administer in a liquid preparation. The lipid-based...
21. March 2016
The development of oral controlled release system has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. Various physical and chemical approaches have been applied to produce a well characterized dosage form that controls drug input into the body within the specifications of the desired release profile. This is generally accomplished by attempting to obtain “zero-order” release from the dosage...
09. March 2016
Abstract: Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. In this paper, the fundamental background on lubrication is introduced, in which the relationships...
20. February 2016
Introduction: This study focused on the potential effects of compression forces experienced during lactose (InhaLac 70, 120, and 230) storage and transport on the flowability and aerosol performance in dry powder inhaler formulation. Materials and Methods: Lactose was subjected to typical compression forces 4, 10, and 20 N/cm2. Powder flowability and particle size distribution analysis of un-compressed and compressed lactose was evaluated by Carr’s index, Hausner’s ratio, the angle of...
17. January 2016
Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have attracted considerable interest as drug delivery vehicles with concomitant considerations of physical characterization, scalability, stability and drug release. In this review, the current thinking with regards to the manufacture of solid amorphous pharmaceutical materials using electrohydrodynamic and gyration-based approaches, melt-spinning...
07. January 2016
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage sustained during the preparation of MUPS tablets in a rotary tablet press. More
05. October 2015
Highlights •Alginate pellets are prepared by air-pressurized melt pelletization technique. •Melt pelletization is conducted in a high shear mixer. •Air-pressurized melt pellets exhibit slow drug release characteristics. •Pellet consolidation within short processing time sustains drug release. •Prolonged air bubbling induces porous core that fails to sustain drug release. More
19. September 2015
Textured mannitol powder is widely used as a pharmaceutical excipient for tablet compaction. In order to choose the right tableting parameters, it is necessary to understand its mechanical behavior during deformation under industrial tableting conditions. More