05. July 2017
The current regulatory environment based on the ICH guidelines encourages a systematic and science-based approach in the pharmaceutical development, required by the “Quality by design” concept.
02. March 2017
Abstract A new and highly biocompatible space holder material is proposed for manufacturing of porous titanium with open and interconnected pore morphologies through powder metallurgy techniques. Sugar pellets are compacted with titanium powder and then removed by dissolution in water before sintering. The morphology, pore structure and porosity were observed by optical microscopy, SEM and micro-CT. The porous titanium has highly spherical pore shapes, well-controlled pore sizes and high...
27. February 2017
Abstract Continuous manufacturing has attracted increasing research attention in the pharmaceutical industry within the last decade. Based on the extensive experimental studies, numerous modeling and computational approaches have been developed to capture the process information and make predictions. Moreover, flowsheet models have been built to simulate the dynamic behaviors of a plant-wide manufacturing process with respect to different process input factors. However, there still lacks a...
11. October 2016
Abstract The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as the model drug, by obtaining an amorphous solid dispersion by hot melt extrusion. Therefore, an initial preformulation study was conducted using differential scanning calorimetry, thermogravimetric analysis and Hansen's solubility parameters in order to find polymers which would have the ability to form amorphous solid dispersions with itraconazole. Afterwards, the four...
02. June 2015
Kalliopi A Chatzizaharia and Dimitrios T Hatziavramidis Ind. Eng. Chem. Res., Just Accepted Manuscript DOI: 10.1021/ie5050567 Publication Date (Web): June 1, 2015 Copyright © 2015 American Chemical Society See more ...