“Design Space” Determination of a Paracetamol Fluid Bed Granulation Using Design of Experiments

Andrea Hartung1,4, Erik Johansson3, Marcus Knoell2, Hedinn Valthorsson4,
Peter Langguth1
1 Department of Pharmaceutical Technology and Biopharmaceutics,
Johannes Gutenberg-University, Mainz, Germany
2 Hüttlin GmbH, Schopfheim, Germany
3 Umetrics AB, Umeå, Sweden
4 Novartis Pharma Stein AG, Stein, Switzerland
Corresponding author: Prof. Peter Langguth, Department of Pharmaceutical Technology
and Biopharmaceutics, Staudingerweg 5, 55099 Mainz, Germany,
e-mail: langguth@uni-mainz.de
http://www.ecv.de/download/download/Zeitschriften/pharmind/volltext/pi-2012-04-0644-hartung-paracetamol.pdf