Release adjustment of drug combinations with different drug solubility
Formulation issues of drug combination in one dosage form could be due to different solubility of drug which will give different release profile. The objective of present study is therefore to adjust the release of two drugs of different solubility in drug for controlled release drug delivery as matrix tablet and multilayer pellet system. As tablet system, employing direct compression method, irrespective to type of polymers, release of propranolol HCl was much faster than carbamazepine due to solubility differences….