Solid State Compatibility Studies of Miconazole Using Thermal and Spectroscopic Methods - Article

Drug excipient physicochemical characterization is a systematic approach towards design of therapeutically active and stable dosage forms. The rapid advancements in novel drug delivery systems have led to an interest by formulation scientists in the role and functionality of the excipients. Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), and Powder X-ray diffractometry (XRD) analytical techniques of high resolution were used to get an insight on solid state properties of the drug and evaluate drug-excipient compatibility. Preformulation studies which were performed using thermal and spectroscopic techniques implied compatibility of phospholipon 90, cholesterol and carbapol 934 excipients with the drug miconazole nitrate.

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