Objetive: To evaluate and compared the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD) composite with common excipients used for the preparation of tablets by direct compression such as polyvinylpirrolidone (Ludipress®), lactose (Cellactose 80®) and microcrystalline cellulose (Prosolv SMCC 90®).
Methods: All materials were tested for lubricant sensitivity, ejection force, elastic recovery, dilution potential and reworking ability. Further, compressibility and compactibility was determined using the Heckel and Leuenberger models, respectively.