13. September 2018

Herein we introduce an innovative process for preparation of directly compressible API and excipient agglomerates for extended release formulation of a highly water soluble drug, demonstrated with metformin HCl. Metformin is poorly compressible and currently employs wet granulation for tablet manufacturing, resulting in long cycle times. We have co-processed metformin HCl with hydroxypropyl methylcellulose (HPMC) and sodium carboxymethlycellulose (NaCMC) in solvent medium to generate...

04. June 2018

Are you a pharmaceutical raw material producer and would like to optimize the handling of your quality documents? Be ahead of the curve As a pharmaceutical raw material producer, sending several high-level quality statements and certificates daily is an essential part of the sales process. What if there were a simpler way? What if a secure, digital platform could enable you to upload quality documents only once and give authorizations to selected customers so they could download those documents...

04. June 2018

The selection of the excipient(s) for a tablet formulation should take into account the API properties, process, target formulation and potential impact on the formulation. Some of those API properties can be Dose Particle Size Flow Properties Bulk Density Moisture Content Hygroscopicity Excipient Compatibility Compactability The following tables show some possible impacts on the tablet formulation and considerations to take into account. Pharmaexcipients.com thanks Fred Monsuur, Grace for the...

26. April 2018

Are you a manufacturer of raw materials for the food, nutraceutical or pharmaceutical industry and interested to increase your product performance or functionality? Are topics like Dust free Solubility Protection Taste masking Targeted release Particle size Flowability relevant to you or for the life cycle management of your product? Then come to speak with the experts from IPC Process Center @Vitafoods Geneva Stand T167 - May 15-17, 2018. If not attending just drop us an email. Further...

01. March 2018

Form changes during drug product processing can be a risk to the final product quality in terms of chemical stability and bioavailability. In this study, online Raman spectroscopy was used to monitor the form changes in real time during high shear wet granulation of Compound A, a highly soluble drug present at a high drug load in an extended release formulation. The effect of water content, temperature, wet massing time and drying technique on the degree of drug transformation were examined.

23. January 2018

Nanotechnology ushered the field of medicine in to a new era. Miniaturization, increased surface area, and the unique physicochemical properties in the nano dimension were explored for new applications. Pharmaceutical industry picked up the technology and early success came fast for oral drug delivery through improvement in dissolution properties of the active molecules. Many products were launched using the nanocrystal technology on the oral side.

30. September 2017

Within the pharmaceutical industry, inline near infrared (NIR) spectroscopy is one of the most commonly applied process analytical technologies to monitor content uniformity of powder blends (1). Inline NIR provides direct insight into blending operations with respect to the degree of uniformity of the ingredient of interest either for process development or control during commercial manufacturing. A quantitative calibration for a specific ingredient may be applied to predict the content of...

06. March 2016

24th May 2016, 9:00 – 16:00 Conservatoire des Arts et Métiers, 292 rue Saint-martin, 75141 Paris Complete Programme Registration