17. September 2018
Anisotropic features with other crystallographic properties like d-spacing,and attachment energy (Eatt) can predict material performance during the secondary pharmaceutical processing. A newly developed state-of-the-art compression cell lodged in apowder X-ray diffractometer was used to measure anisotropic Young’s moduli (YM) of flufenamic acid (FFA) polymorphs in this study. Methodology is based on the generation of a single crystal deformation in this cell, which reflects as a change in the...
29. February 2016
The relevance of solid form in drug development has been well established over time. In order to fully understand drug properties, attention has been paid to solid state structure of drug molecules and their relationship to the drug formulation. While each drug developer has had their own strategies and workflows for screening and choosing solid forms of drug molecules, the industry is aware of instances where “the best laid plans” often go awry. This manuscript has summarized several case...
22. April 2015
Highlights • IR spectroscopy showed absence of chemical interaction between excipients and drug. • In thermal analysis physical interaction between excipients and drug was identified. • Some excipients promoted but some reduced stability of the API unstable polymorph. • Phase transition rate of API depended on the type and the amount of excipient added. http://www.sciencedirect.com/science/article/pii/S0731708514006384