The effect of excipients on the stability and phase transition rate of xylazine hydrochloride and zopiclone.

Highlights

• IR spectroscopy showed absence of chemical interaction between excipients and drug.

• In thermal analysis physical interaction between excipients and drug was identified.

• Some excipients promoted but some reduced stability of the API unstable polymorph.

• Phase transition rate of API depended on the type and the amount of excipient added.

http://www.sciencedirect.com/science/article/pii/S0731708514006384