Buccal Transmucosal Delivery System of Enalapril for Improved Cardiac Drug Delivery: Preparation and Characterization

Purpose: To prepare and characterize buccal transmucosal delivery system of enalapril maleate for overcoming its low bioavailability, and hence provide improved therapeutic efficacy and patient compliance.

Methods: Transmucosal drug delivery systems of enalapril maleate were formulated as buccal films by solvent casting technique using polyvinylpyrrolidone K90, hydroxypropyl methylcellulose, sodium carboxymethylcellulose (high viscosity). The films were evaluated for film weight, thickness, folding endurance, drug content uniformity, surface pH, in vitro residence time, in vitro drug release and ex-vivo permeation.

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Buccal Transmucosal Delivery System of Enalapril for Improved Cardiac Drug Delivery: Preparation and Characterization
Wen-Shuai He, Hao-Wei Xiong, Dan Xi, Tian-Tian Luo, Hao Lu, Meng-Hao Li, Ji-
Cheng Liu and Zhi-Gang Guo*
Division of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
*For correspondence: Email: guozhg51@gmail.com; Tel/Fax: 0086-20-61641508
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