ABSTRACT
For pharmaceutical tablet prodution, there are lots of commercial excipients available. All these excipients influence the drug release of tablet cores in different ways. In this project the influence of Carbopol 71G®, Carbopol 971P®, Fujicalin®, Neusilin US2®, Neusilin UFL2®, Pemulen TR-1®, Pemulen TR-2®, Sepistab ST 200® and Sepitrap 80® on drug release was investigated. Tablets were compressed with resveratrol as a model drug using an eccentric press. Tablets containing 2 wt.% of resveratrol which was mixed with a certain amount of excipient, in addition to 1 wt.% of talc, 1 wt.% magnesium stearate and Ludipress LCE. These products were compared with tablets without any excipients, but with all the other remaining components of the formulation. Drug release was in vitro investigated in dependence of time, according to European Pharmacopoeia (Ph. Eur. 2.9.3). It appeared that drug release depends on the qualities of the pharmaceutical additives. Tablets with Fujicalin® and Sepistab ST 200® exhibit a rapid release and disintegration time, while the other pharmaceu cal additives lead to a delayed release (retardation). Drug release kinetics was described by the mathematical model of Korsmeyer-Peppas.
1Beuth Hochschule für Technik Berlin - University of Applied Sciences, Faculty of Mathematics-Physics-Chemistry, Pharmaceutical and Chemical Engineering, Luxemburger Str. 10, D-13353 Berlin, Germany.