Predicting Multiparticulate Dissolution in Real Time for Modified- and Extended- Release Formulations

Process analytical technology, based on monitoring particle size distribution and tracking coating thickness measurements in real time, can be used to predict the dissolution of polymer-coated multiparticulates.

 

Process analytical technology, based on monitoring particle size distribution and tracking coating thickness measurements in real time, can be used to predict the dissolution of polymer-coated multiparticulates.Process analytical technology (PAT) describes the use of analytical instruments to measure specific product attributes during manufacturing, substantially minimizing the need to sample product for off-line analysis. This approach offers several key advantages including the ability to take process measurements in situ, with instant access to data, facilitating rapid decision making during product development and manufacturing.

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Predicting Multiparticulate Dissolution in Real Time for Modified- and Extended- Release Formulations
Apr 01, 2017


By Piyush Patel, Edward Godek, Chris O’Callaghan, Ian Jones

Pharmaceutical Technology

Volume 2017 Supplement, Issue 2, pg s20-s25
Predicting Multiparticulate Dissolution
Adobe Acrobat Document 573.6 KB