Preparation of Bitter Taste-Masking Granules of Lafutidine for Orally Disintegrating Tablets using Water-Insoluble/Soluble Polymer Combinations

Taste-masking granules were prepared by coating granules with a taste-masking layer prepared by combining the water-insoluble and -soluble polymers, ethylcellulose and hypromellose, respectively. These granules showed an immediate drug release property after a suitable lag time. We confirmed that the dissolution behavior depended on the polymer ratio in the taste-masking layer. The result showed that the dissolution lag time and rate of the taste-masking granules were shortened and enhanced, respectively by increasing the hypromellose content. 

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