Formulation and Evaluation of Coprocessed Excipient for MouthDissolving Formulation

In the present study an attempt has been made to evaluate Ocimum bascilium mucilage coprocessed with Mannitol as a novel super disintegrant. Coprocessed excipients were prepared by solvent evaporation method and evaluated in the formulation of mouth dissolving tablets of Terbutaline sulphate. Formulated mouth dissolving tablets were characterised for physicochemical parameters like hardness, friability, weight variation, disintegration time, drug content and in vitro drug release behaviour. The outcomes of physicochemical evaluation of formulations showed that all developed formulations had desirable features. The coprocessed mucilage (Mannitol: Mucilage) exhibited disintegration within 8 sec at the concentration of 1 gm: 65 mg as compared to the coprocessed Mannitol: SSG which disintegrated within 11 sec at the concentration of 1 gm: 85 mg. The developed excipient showed improvement in parent excipient functionalities and proving coprocessed mucilage of Ocimum bascilium to be an excellent novel superdisintegrant in mouth dissolving formulation and thus it can be exploited commercially.

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Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation
Gandhi PP and Mundada AS*
Department of Pharmaceutics, SSDJ College of Pharmacy, Neminagar, Chandwad, Nasik, Maharashtra, India
*Corresponding author: Mundada AS, Department of Pharmaceutics, SSDJ College of Pharmacy, Neminagar, Chandwad, Nasik-423 101, Maharashtra, India, Tel:
+919224360591; E-mail: atishmundada@rediffmail.com
Received December 16, 2015; Accepted January 27, 2016; Published January 30, 2016
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