ABSTRACT
The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as the release kinetics of the drug. The IBP was crystallized on the gel surface of HPC/PAAm, it had a prismatic shape and the growth was made in an aqueous medium, the crystallinity grade of the gel HPC/PAAm and HPC/PAAm-IBU were to 65 and 58. % respectively. The release of IBP is performed by two means: by a non–Fickian diffusion process, and by relaxation of the chains of the gel; without regard of temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel. This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C. Krossmeyer and Peppas mathematical model was simulate for data releases, are statistically significant at 95% confidence level.
